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Preventing diabetes—time is running out
Robert Scragg
These days we are continually bombarded in the popular press
about the current obesity epidemic and the resulting tidal wave of diabetes
expected soon to cover Aotearoa (New Zealand). Indeed, despite predictions of an
80% increase in the number of people with diabetes during the 15 year period
from 1996 to 2011,1 a degree of apathy and
indifference appears to prevail among influential circles in the Ministry of
Health and District Health Boards, creating the impression that these organs of
Government believe there is plenty of time left to put diabetes preventive
strategies in place and that urgent measures are not required.
The article by Tipene-Leach and
colleagues,2 in this issue of the
Journal, comes as a wake up
call—to everyone—that time is running out. The very high prevalences
of insulin resistance among Maori from the east coast north of Gisborne,
particularly in young adults below 40 years of age, indicate that the main
pathophysiological precursor of type 2 diabetes is already well-established in
our midst.
The study is the first within New Zealand to document the
prevalence of insulin resistance in a community sample, using the authors own
method based on fasting insulin and triglycerides, which has higher sensitivity
and specificity compared with other population measures of insulin
resistance.3 Half (51%) of participants aged
25–39 years in this survey had insulin resistance (including diabetes).
As a check, the authors calculated the prevalence of the
metabolic syndrome in their sample using the United States’ (US) Adult
Treatment Panel III definition;4 which was 34%
in the 25–39 year age group, much higher than 12–14% reported for
30–39 year old participants in the 3rd
National Health and Nutrition Examination Survey from the
US.5
Can the results from this East Coast study be applied to
Maori across the whole of New Zealand? The relatively small sample size (n=247)
means that confidence intervals (and the degree of uncertainty) around
prevalence estimates are quite wide. Furthermore, the low response rate may have
led to selection bias, but given that responders are usually healthier than
non-responders, the survey may have actually under-estimated the prevalence of
insulin resistance.
Indeed, the prevalence of obesity in this study (67% with
body mass index (BMI)≥30) is higher than that reported for Maori in the
2002-2003 National Health Survey (about 30% with
BMI≥32).6
If obesity is the only driver of insulin resistance, then it
is quite likely that the prevalence of insulin resistance is lower among the
wider Maori community than reported in this paper. A south Auckland
cross-sectional survey has previously reported higher insulin levels in Maori
(and Pacific) people, compared with European, which are entirely due to ethnic
differences in BMI.7 In contrast, the Workforce
Survey showed that the diabetes prevalence in Maori remained elevated after
adjusting for BMI.8 So it is possible the very
high insulin resistance prevalences reported in the study by Tipene-Leach and
colleagues may not be due exclusively to the very high obesity levels in their
study sample.
Other possible lifestyle factors contributing to the high
prevalence of insulin resistance among Maori in this survey include: a diet high
in animal fats, a risk factor for diabetes9
which is increased in Maori (and Pacific people) compared with Europeans
;10 and decreased physical
activity—although nationally, Maori are more likely to do regular physical
activity than other ethnic groups.6
As the study authors rightly conclude, a national survey of
diabetes and insulin resistance is urgently required to confirm whether the very
high prevalences of insulin resistance reported in their study occur more widely
across New Zealand in Maori and in others who are also at high risk of diabetes
such as the Pacific and Asian communities.
If very high prevalences of insulin resistance do occur in
these ethnic groups, then the Ministry of Health and District Health Boards have
a huge problem on their hands, with much bigger consequences than those they are
trying to prevent via the multi-million dollar meningococcal vaccination
campaign currently underway in the North Island.
The Ministry of Health is to be lauded for driving through
its ‘Get Checked’ programme to improve the clinical management of
diabetes by providing free annual medical checks to diabetes patients. It now
needs to show the same conviction (and funding) towards implementing programmes
for preventing diabetes.
The recent PricewaterhouseCoopers report shows that the
health cost savings from a diabetes prevention programme are likely to be
greater than programme itself.11 While there
has been some investment by the Ministry of Health and District Health Boards
into the development of diabetes prevention programmes, it is miniscule compared
to funding of prevention programmes for other diseases, such as meningococcal
meningitis and cancer screening.
The high levels of insulin resistance among young adults
reported in the article by Tipene-Leach and colleagues indicates there is little
time left to implement preventive strategies on a national basis. Continuing
failure by the Ministry of Health to commit the funds required now for diabetes
prevention will result in much greater health costs downstream, than currently,
and many more people will suffer with diabetes.
Author information:
Robert Scragg, Epidemiology & Biostatistics, School of Population Health,
University of Auckland, Auckland
Correspondence:
Assoc Prof Robert Scragg, Epidemiology & Biostatistics, School of Population
Health, University of Auckland, Private Bag, Auckland. Fax: (09) 373 7624;
email: r.scragg@auckland.ac.nz
References:
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