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The legacy of Sir Charles Hercus
Your excerpt from Dr Colquhoun’s
paper1 of 1910—100 years
ago—showing the complete mystery of the cause of Graves’ disease, is
a timely reminder of the monumental contribution made by Sir Charles Hercus,
Dean of the Otago Medical School. He fostered research by setting up
disease-removing full-time research units, manned by hand-picked people with
especial research talent.
In this way, Hercus got rid of:
...And
discovered the cause of Graves’ disease. It is an autoimmune disease and
has pioneered discovery of this great category of diseases, which are now ripe
for prevention or cure by negating the microbial triggers or selective
destruction of the pathogenic forbidden
clones.2
This is a wonderful legacy from a very great man, whose
methods should be copied by today’s leaders.
Hercus was descended from Shetland Island Vikings. The
Vikings invading Normandy, found the French language better than their own, so
they adopted it! They also copied the French in riding horses. This virtue of
preserving and adopting anything good that was better than what they had
themselves, contrasts strikingly with the Mongols. As well as plaguing the
Chinese, the Mongols ruthlessly destroyed anything different from their own,
including the great, civilised Muslim Arab Empire set up by
Mohammed.3
Endowed with Norman virtues, Hercus was fearless in seeking
to use all available talented people for getting rid of disease. His greatest
asset was Dick Purves, with Honours degrees in Physics and Chemistry, who could
take medical problems back to their basis in mathematics, physics or chemistry.
Hercus and Purves abolished New Zealand’s goitre
endemic, saving countless thyroid operations and the birth of cretinous
children. Then with Walter Griesbach and Tom Kennedy, Purves solved pituitary
cytology, developed Endocrinology, discovered antithyroid drugs for medical
treatment of thyrotoxicosis and set up the research with radioactive iodine that
led to discovery that Graves’ disease of the thyroid is an autoimmune
disease. These were monumental research achievements.
For seeking talent Hercus applied to the medical course the
formal university tradition of a Bachelor’s degree, based on attendance at
lectures followed by passing an examination, then a Master’s degree, based
on writing a thesis which contributed to knowledge. Accordingly, Hercus had his
medical students write a thesis in the 5th year of the course, its great virtue
being that the student chose the topic, rather than having it suggested by a
supervisor. This enabled originality to be shown. I wrote a thesis on asthma
that showed fledgling research ability and caused Hercus to recruit me as an
apprentice to Purves 3 years later.
Duncan Adams
Honorary Research Fellow in the Faculty of Medicine (Previously Director of the MRC Autoimmunity Research Unit) University of Otago, Dunedin References:
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