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Issue

Vol 128 No 1416: 12 June 2015

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Issue Summary

SUMMARY

Whooping cough—where are we now? A review

Tomasz Kiedrzynski, Ange Bissielo, Mishra Suryaprakash, Don Bandaranayake

This paper describes the recent trends of pertussis and vaccine uptake in New Zealand based on notifications and immunisation registration information since 2011. It highlights the current risk for the infant in the first months after birth and the crucial role a pertussis booster in pregnancy could play. It also aims to show that protection of infants by the current vaccine can be improved by timely immunisation even in a situation of improving overall uptake rates that are nearing the national target of 95%.

SUMMARY

An important investment to control Acute Rheumatic Fever needs to run its course

Diana Lennon, Joanna Stewart

Rheumatic Fever reduces life spans by 10 years, but is preventable. Current school programmes to prevent it in high-risk areas are promising, but numbers needed to prove it is working to prevent rheumatic fever. The Ministry of Health has co-funded the school programmes with DHBs, but is handing over to the DHBs before there is proof that the programme is effective (numbers need to accrue to prove statistical significance). DHBs may not continue to fund and have no evidence to inform their funding choices. This is a short-term wasted investment.

SUMMARY

Karyotypes, confined blood chimerism, and confusion: a case of genetic sex mislabelling and its potential consequences

Aarthi Ravishankar, Jos\u00e9 G B Derraik, Sarah Mathai, Wayne S Cutfield, Paul L Hofman

Disorders of sex development (DSD) encompass a range of conditions which at their extreme can present as boys appearing like normal girls and girls appearing like normal boys. The management of infants with DSD can be extremely complex, requiring the long-term involvement of a multidisciplinary team working alongside the family. However, in some cases a normal infant may be wrongly labelled as having DSD, which may lead to irreversible consequences such as inappropriate surgery. This case illustrates how easily this can occur. The infants blood had a normal male 46 XY karyotype due to bone marrow transplant from the male twin while the other tissues were a normal female 46XX karyotype. This led to an incorrect sex determination at birth and almost to the potentially disastrous surgical removal of normal ovaries.

ALL ARTICLES
SUMMARY

Whooping cough—where are we now? A review

Tomasz Kiedrzynski, Ange Bissielo, Mishra Suryaprakash, Don Bandaranayake

Direct access GP referral for ETT functions as a virtual clinic

Jessica Greaves, Joan Leighton, John Lainchbury, Paul Bridgman

Recalcitrant peripheral spondyloarthritis treated with radiotherapy

Nur Azri Bin Haji Mohd Yasin, Shaun Costello

Uptake of new medicines: the Pharmaceutical Management Agency of New Zealand (PHARMAC) in the international context

Rajan Ragupathy, Zaheer-Ud-Din Babar

An important investment to control Acute Rheumatic Fever needs to run its course

Diana Lennon, Joanna Stewart

Improving our strategy to prevent and control measles outbreaks

Lance Gravatt

The War, the Birth Rate, and Strong Drink

Karyotypes, confined blood chimerism, and confusion: a case of genetic sex mislabelling and its potential consequences

Aarthi Ravishankar, Jos\u00e9 G B Derraik, Sarah Mathai, Wayne S Cutfield, Paul L Hofman

Randomised trial of peanut consumption in infants at risk for peanut allergy

Domperidone safety: a mini-review of the science of QT prolongation and clinical implications of recent global regulatory recommendations

Pamela J Buffery, R. Matthew Strother

Not a simple back pain

Jen-Li Looi, Ruvin Gabriel

HIV-associated tuberculosis in Auckland

Christopher Luey, David Milne, Simon Briggs, Mark Thomas, Rupert Handy, Mitzi Nisbet

Barriers to successful cessation among young  late-onset smokers

Hayley Guiney, Judy Li, Darren Walton

SUMMARY

Whooping cough—where are we now? A review

Tomasz Kiedrzynski, Ange Bissielo, Mishra Suryaprakash, Don Bandaranayake

This paper describes the recent trends of pertussis and vaccine uptake in New Zealand based on notifications and immunisation registration information since 2011. It highlights the current risk for the infant in the first months after birth and the crucial role a pertussis booster in pregnancy could play. It also aims to show that protection of infants by the current vaccine can be improved by timely immunisation even in a situation of improving overall uptake rates that are nearing the national target of 95%.

SUMMARY

An important investment to control Acute Rheumatic Fever needs to run its course

Diana Lennon, Joanna Stewart

Rheumatic Fever reduces life spans by 10 years, but is preventable. Current school programmes to prevent it in high-risk areas are promising, but numbers needed to prove it is working to prevent rheumatic fever. The Ministry of Health has co-funded the school programmes with DHBs, but is handing over to the DHBs before there is proof that the programme is effective (numbers need to accrue to prove statistical significance). DHBs may not continue to fund and have no evidence to inform their funding choices. This is a short-term wasted investment.

SUMMARY

Karyotypes, confined blood chimerism, and confusion: a case of genetic sex mislabelling and its potential consequences

Aarthi Ravishankar, Jos\u00e9 G B Derraik, Sarah Mathai, Wayne S Cutfield, Paul L Hofman

Disorders of sex development (DSD) encompass a range of conditions which at their extreme can present as boys appearing like normal girls and girls appearing like normal boys. The management of infants with DSD can be extremely complex, requiring the long-term involvement of a multidisciplinary team working alongside the family. However, in some cases a normal infant may be wrongly labelled as having DSD, which may lead to irreversible consequences such as inappropriate surgery. This case illustrates how easily this can occur. The infants blood had a normal male 46 XY karyotype due to bone marrow transplant from the male twin while the other tissues were a normal female 46XX karyotype. This led to an incorrect sex determination at birth and almost to the potentially disastrous surgical removal of normal ovaries.

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