Hepatitis B virus-related hepatocellular carcinoma presenting at an advanced stage: is it preventable?
Thomas Mules, Ed Gane, Oonagh Lithgow, Adam Bartlett, John McCall
This study evaluated which factors are associated with late presentation of hepatitis B (HBV) related hepatocellular carcinoma (HCC) by retrospectively reviewing all cases of HBV-related HCC diagnosed with late-stage/incurable HCC in New Zealand between 2003 and 2017. This study found that the incidence of patients presenting with incurable HBV-related HCC is increasing, HBV-related HCC disproportionately affects minority ethnic groups, diagnosis of HCC before the diagnosis of the underlying HBV is associated with poor survival (median 90 days), and optimal HCC surveillance significantly improves patient survival. This study has highlighted the need for improved rates of HBV diagnosis, better follow-up of those infected, and the importance of optimal HCC surveillance. In New Zealand, HBV-related HCC disproportionately affects minority ethnic groups, and given the increasing incidence, provides a potential domain to reduce health inequities.