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Alcohol intake and risk of breast cancer and coronary heart disease among postmenopausal womenThe question addressed in this study is whether postmenopausal women who increase their alcohol intake over a five year period have a higher risk of breast cancer and lower risk of coronary heart disease than those who maintain their stable alcohol intake?21,523 postmenopausal women who participated in the Diet, Cancer, and Health study in Denmark were eligible for the study. Change in alcohol intake was recorded and incidence of breast cancer and coronary heart disease was noted during an 11 year follow-up. The researchers found that those who increased their alcohol intake over a 5-year period had a higher risk of breast cancer and a lower risk of coronary heart disease.The authors of the study note that alcohol intake was self-reported and possibly underestimated. Nevertheless, the results support the hypotheses that alcohol is associated with breast cancer and coronary heart disease in opposite directions. BMJ 2016;353:i2314 Serious asthma events with fluticasone plus salmeterol versus fluticasone aloneThe safe and appropriate use of long-acting beta-agonists (LABAs) for the treatment of asthma has been widely debated.This study was designed to evaluate the risk of administering the LABA salmeterol in combination with an inhaled glucocorticoid, fluticasone propionate.Over 11,000 patients over the age of 12 years with persistent asthma were randomised to receive inhaled fluticasone alone or fluticasone with salbutamol for 26 weeks. Patients with life-threatening or unstable asthma were excluded. 67 patients suffered serious asthma-related events, 34 in the fluticasone-salmeterol group and 33 in the fluticasone only group. The risk of a severe exacerbation was 21% lower in the fluticasone-salmeterol group.The conclusion reached was that patients who received salmeterol in a fixed-dose combination with fluticasone did not have a significantly higher risk of serious asthma-related events than did those who received fluticasone alone. The risk of severe asthma exacerbations was significantly lower in the combination treated patients. N Engl J Med 2016;374:1822-30 Endovascular thrombectomy after large-vessel ischaemic strokeIn 2015, five randomised trials showed efficacy of endovascular thrombectomy over standard medical care in patients with acute ischaemic stroke caused by occlusion of arteries of the proximal anterior circulation. As each of these trials were moderate in size there is uncertainty about the benefits of this treatment in certain patients, including those who presented to treatment late, are elderly, have mild deficits and are not eligible for intravenous alteplase.This meta-analysis examines data pooled from these trials. The researchers analysed individual data for 1,287 patients (634 assigned to endovascular thrombectomy, 653 assigned to standard care). The conclusions reached were that endovascular thrombectomy is of benefit to most patients with acute ischaemic stroke caused by occlusion of the proximal anterior circulation, irrespective of patient characteristics or geographical location. Lancet 2016;387:1723-31

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Alcohol intake and risk of breast cancer and coronary heart disease among postmenopausal womenThe question addressed in this study is whether postmenopausal women who increase their alcohol intake over a five year period have a higher risk of breast cancer and lower risk of coronary heart disease than those who maintain their stable alcohol intake?21,523 postmenopausal women who participated in the Diet, Cancer, and Health study in Denmark were eligible for the study. Change in alcohol intake was recorded and incidence of breast cancer and coronary heart disease was noted during an 11 year follow-up. The researchers found that those who increased their alcohol intake over a 5-year period had a higher risk of breast cancer and a lower risk of coronary heart disease.The authors of the study note that alcohol intake was self-reported and possibly underestimated. Nevertheless, the results support the hypotheses that alcohol is associated with breast cancer and coronary heart disease in opposite directions. BMJ 2016;353:i2314 Serious asthma events with fluticasone plus salmeterol versus fluticasone aloneThe safe and appropriate use of long-acting beta-agonists (LABAs) for the treatment of asthma has been widely debated.This study was designed to evaluate the risk of administering the LABA salmeterol in combination with an inhaled glucocorticoid, fluticasone propionate.Over 11,000 patients over the age of 12 years with persistent asthma were randomised to receive inhaled fluticasone alone or fluticasone with salbutamol for 26 weeks. Patients with life-threatening or unstable asthma were excluded. 67 patients suffered serious asthma-related events, 34 in the fluticasone-salmeterol group and 33 in the fluticasone only group. The risk of a severe exacerbation was 21% lower in the fluticasone-salmeterol group.The conclusion reached was that patients who received salmeterol in a fixed-dose combination with fluticasone did not have a significantly higher risk of serious asthma-related events than did those who received fluticasone alone. The risk of severe asthma exacerbations was significantly lower in the combination treated patients. N Engl J Med 2016;374:1822-30 Endovascular thrombectomy after large-vessel ischaemic strokeIn 2015, five randomised trials showed efficacy of endovascular thrombectomy over standard medical care in patients with acute ischaemic stroke caused by occlusion of arteries of the proximal anterior circulation. As each of these trials were moderate in size there is uncertainty about the benefits of this treatment in certain patients, including those who presented to treatment late, are elderly, have mild deficits and are not eligible for intravenous alteplase.This meta-analysis examines data pooled from these trials. The researchers analysed individual data for 1,287 patients (634 assigned to endovascular thrombectomy, 653 assigned to standard care). The conclusions reached were that endovascular thrombectomy is of benefit to most patients with acute ischaemic stroke caused by occlusion of the proximal anterior circulation, irrespective of patient characteristics or geographical location. Lancet 2016;387:1723-31

Summary

Abstract

Aim

Method

Results

Conclusion

Author Information

Acknowledgements

Correspondence

Correspondence Email

Competing Interests

For the PDF of this article,
contact nzmj@nzma.org.nz

View Article PDF

Alcohol intake and risk of breast cancer and coronary heart disease among postmenopausal womenThe question addressed in this study is whether postmenopausal women who increase their alcohol intake over a five year period have a higher risk of breast cancer and lower risk of coronary heart disease than those who maintain their stable alcohol intake?21,523 postmenopausal women who participated in the Diet, Cancer, and Health study in Denmark were eligible for the study. Change in alcohol intake was recorded and incidence of breast cancer and coronary heart disease was noted during an 11 year follow-up. The researchers found that those who increased their alcohol intake over a 5-year period had a higher risk of breast cancer and a lower risk of coronary heart disease.The authors of the study note that alcohol intake was self-reported and possibly underestimated. Nevertheless, the results support the hypotheses that alcohol is associated with breast cancer and coronary heart disease in opposite directions. BMJ 2016;353:i2314 Serious asthma events with fluticasone plus salmeterol versus fluticasone aloneThe safe and appropriate use of long-acting beta-agonists (LABAs) for the treatment of asthma has been widely debated.This study was designed to evaluate the risk of administering the LABA salmeterol in combination with an inhaled glucocorticoid, fluticasone propionate.Over 11,000 patients over the age of 12 years with persistent asthma were randomised to receive inhaled fluticasone alone or fluticasone with salbutamol for 26 weeks. Patients with life-threatening or unstable asthma were excluded. 67 patients suffered serious asthma-related events, 34 in the fluticasone-salmeterol group and 33 in the fluticasone only group. The risk of a severe exacerbation was 21% lower in the fluticasone-salmeterol group.The conclusion reached was that patients who received salmeterol in a fixed-dose combination with fluticasone did not have a significantly higher risk of serious asthma-related events than did those who received fluticasone alone. The risk of severe asthma exacerbations was significantly lower in the combination treated patients. N Engl J Med 2016;374:1822-30 Endovascular thrombectomy after large-vessel ischaemic strokeIn 2015, five randomised trials showed efficacy of endovascular thrombectomy over standard medical care in patients with acute ischaemic stroke caused by occlusion of arteries of the proximal anterior circulation. As each of these trials were moderate in size there is uncertainty about the benefits of this treatment in certain patients, including those who presented to treatment late, are elderly, have mild deficits and are not eligible for intravenous alteplase.This meta-analysis examines data pooled from these trials. The researchers analysed individual data for 1,287 patients (634 assigned to endovascular thrombectomy, 653 assigned to standard care). The conclusions reached were that endovascular thrombectomy is of benefit to most patients with acute ischaemic stroke caused by occlusion of the proximal anterior circulation, irrespective of patient characteristics or geographical location. Lancet 2016;387:1723-31

Summary

Abstract

Aim

Method

Results

Conclusion

Author Information

Acknowledgements

Correspondence

Correspondence Email

Competing Interests

Contact diana@nzma.org.nz
for the PDF of this article

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