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Case—A 27-year-old female with hypocellular myelodysplastic syndrome underwent matched unrelated donor allogeneic stem cell transplantation in July 2011. She presented with diarrhoea 3 weeks after transplant and was diagnosed as acute graft versus host disease of the gut. She did not respond to steroids and was treated with infliximab (antiTNFα monoclonal antibody), pentostatin and abatacept (CTLA4-IgG fusion protein) with minimal response.She developed dark-coloured necrotic-appearing papules on her skin (Figure 1) which were biopsied. Culture plate showed grayish-black colonies (Figure 2). Septated hyphae with sporulation were noted on microscopy (Figure 3). Figure 1. Patient with papules on her face Figure 2. Sabouraud agar plate with grayish black colonies Figure 3. Lactophenol Cotton Blue Wet mount preparation showing septate hyphae with sporulation (magnification 40×) What is the diagnosis? Answer and Discussion

Summary

Abstract

Aim

Method

Results

Conclusion

Author Information

David McBride, Associate Professor in Occupational Health, Leo Schep, Toxicologist, National Poisons Centre, Department of Preventive and Social Medicine, University of Otago, Dunedin School of Medicine

Acknowledgements

Correspondence

Correspondence Email

Competing Interests

Berg D, Garcia JA, Schell WA, et al. Cutaneous infection caused by Curvularia pallescens: a case report and review of the spectrum of disease. J Am Acad Dermatol. 1995 Feb;32(2 Pt 2):375-8. Review.Safdar A. Curvularia-favorable response to oral itraconazole therapy in two patients with locally invasive phaeohyphomycosis. Clin Microbiol Infect. 2003 Dec;9(12):1219-23.

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Case—A 27-year-old female with hypocellular myelodysplastic syndrome underwent matched unrelated donor allogeneic stem cell transplantation in July 2011. She presented with diarrhoea 3 weeks after transplant and was diagnosed as acute graft versus host disease of the gut. She did not respond to steroids and was treated with infliximab (antiTNFα monoclonal antibody), pentostatin and abatacept (CTLA4-IgG fusion protein) with minimal response.She developed dark-coloured necrotic-appearing papules on her skin (Figure 1) which were biopsied. Culture plate showed grayish-black colonies (Figure 2). Septated hyphae with sporulation were noted on microscopy (Figure 3). Figure 1. Patient with papules on her face Figure 2. Sabouraud agar plate with grayish black colonies Figure 3. Lactophenol Cotton Blue Wet mount preparation showing septate hyphae with sporulation (magnification 40×) What is the diagnosis? Answer and Discussion

Summary

Abstract

Aim

Method

Results

Conclusion

Author Information

David McBride, Associate Professor in Occupational Health, Leo Schep, Toxicologist, National Poisons Centre, Department of Preventive and Social Medicine, University of Otago, Dunedin School of Medicine

Acknowledgements

Correspondence

Correspondence Email

Competing Interests

Berg D, Garcia JA, Schell WA, et al. Cutaneous infection caused by Curvularia pallescens: a case report and review of the spectrum of disease. J Am Acad Dermatol. 1995 Feb;32(2 Pt 2):375-8. Review.Safdar A. Curvularia-favorable response to oral itraconazole therapy in two patients with locally invasive phaeohyphomycosis. Clin Microbiol Infect. 2003 Dec;9(12):1219-23.

For the PDF of this article,
contact nzmj@nzma.org.nz

View Article PDF

Case—A 27-year-old female with hypocellular myelodysplastic syndrome underwent matched unrelated donor allogeneic stem cell transplantation in July 2011. She presented with diarrhoea 3 weeks after transplant and was diagnosed as acute graft versus host disease of the gut. She did not respond to steroids and was treated with infliximab (antiTNFα monoclonal antibody), pentostatin and abatacept (CTLA4-IgG fusion protein) with minimal response.She developed dark-coloured necrotic-appearing papules on her skin (Figure 1) which were biopsied. Culture plate showed grayish-black colonies (Figure 2). Septated hyphae with sporulation were noted on microscopy (Figure 3). Figure 1. Patient with papules on her face Figure 2. Sabouraud agar plate with grayish black colonies Figure 3. Lactophenol Cotton Blue Wet mount preparation showing septate hyphae with sporulation (magnification 40×) What is the diagnosis? Answer and Discussion

Summary

Abstract

Aim

Method

Results

Conclusion

Author Information

David McBride, Associate Professor in Occupational Health, Leo Schep, Toxicologist, National Poisons Centre, Department of Preventive and Social Medicine, University of Otago, Dunedin School of Medicine

Acknowledgements

Correspondence

Correspondence Email

Competing Interests

Berg D, Garcia JA, Schell WA, et al. Cutaneous infection caused by Curvularia pallescens: a case report and review of the spectrum of disease. J Am Acad Dermatol. 1995 Feb;32(2 Pt 2):375-8. Review.Safdar A. Curvularia-favorable response to oral itraconazole therapy in two patients with locally invasive phaeohyphomycosis. Clin Microbiol Infect. 2003 Dec;9(12):1219-23.

Contact diana@nzma.org.nz
for the PDF of this article

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