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Treatment strategies for women with WHO group II anovulation

This report concerns a meta-analysis of trials on the topic of what is the most effective first line treatment for women with World Health Oganization group II anovulation wishing to conceive.

The data includes randomised controlled trials comparing eight ovulation induction treatments in these women. These treatments included clomiphene, letrozole, metformin, clomiphene and metformin combined, tamoxifen, gonadotrophins, laparoscopic ovarian drilling and placebo or no treatment. Pregnancy, defined preferably as clinical pregnancy, was chosen as the primary outcome.

Fifty-seven trials reporting on 8,082 women were included. All treatments were superior to placebo or no treatment in terms of pregnancy. The researchers concluded that letrozole and the combination of clomiphene and metformin are superior to clomiphene alone in terms of pregnancy.

BMJ 2017; 356:j138

Thromboprophylaxis after knee arthroscopy and lower-leg casting

The use of pharmacologic thromboprophylaxis after most orthopaedic interventions is well established, because it strongly reduces the risk of thrombosis while only slightly increasing the risk of bleeding. However, whether such treatment is beneficial after arthroscopy or lower-leg casting is disputed.

Two randomised trials conducted in the Netherlands examine this proposition. Patients were assigned to receive either low-molecular-weight heparin for eight days after arthroscopy or during the full period of casting or no anticoagulant therapy.

The incidence of venous thromboembolism was low in both trials and its incidence was uninfluenced by the use of anticoagulation.

N Engl J Med 2017; 376:515–25

Obesity and hypertension in Australian young people

This study aimed to characterise the prevalence of obesity and systolic hypertension in young people aged 15–24 years across Australia.

Data was obtained from the Australian Health Survey. Over 2,000 young people were involved. In males, the prevalence of obesity increased from 8% to 15% through the ages of 15–24 years. The prevalence of overweight and obesity were both 14% for females across all age groups. The prevalence of hypertension was low (4% males and 3% females) but the prevalence of high normal blood pressure was substantial (males 28% and females 14%).

In their summary, the authors noted that overweight, obesity and high normal blood pressure were highly prevalent among Australian young people. Low levels of physical activity were identified as a risk factor for obesity for both male and females.

Internal Medicine Journal 2017; 47:162–169

Summary

Abstract

Aim

Method

Results

Conclusion

Author Information

Acknowledgements

Correspondence

Correspondence Email

Competing Interests

For the PDF of this article,
contact nzmj@nzma.org.nz

View Article PDF

Treatment strategies for women with WHO group II anovulation

This report concerns a meta-analysis of trials on the topic of what is the most effective first line treatment for women with World Health Oganization group II anovulation wishing to conceive.

The data includes randomised controlled trials comparing eight ovulation induction treatments in these women. These treatments included clomiphene, letrozole, metformin, clomiphene and metformin combined, tamoxifen, gonadotrophins, laparoscopic ovarian drilling and placebo or no treatment. Pregnancy, defined preferably as clinical pregnancy, was chosen as the primary outcome.

Fifty-seven trials reporting on 8,082 women were included. All treatments were superior to placebo or no treatment in terms of pregnancy. The researchers concluded that letrozole and the combination of clomiphene and metformin are superior to clomiphene alone in terms of pregnancy.

BMJ 2017; 356:j138

Thromboprophylaxis after knee arthroscopy and lower-leg casting

The use of pharmacologic thromboprophylaxis after most orthopaedic interventions is well established, because it strongly reduces the risk of thrombosis while only slightly increasing the risk of bleeding. However, whether such treatment is beneficial after arthroscopy or lower-leg casting is disputed.

Two randomised trials conducted in the Netherlands examine this proposition. Patients were assigned to receive either low-molecular-weight heparin for eight days after arthroscopy or during the full period of casting or no anticoagulant therapy.

The incidence of venous thromboembolism was low in both trials and its incidence was uninfluenced by the use of anticoagulation.

N Engl J Med 2017; 376:515–25

Obesity and hypertension in Australian young people

This study aimed to characterise the prevalence of obesity and systolic hypertension in young people aged 15–24 years across Australia.

Data was obtained from the Australian Health Survey. Over 2,000 young people were involved. In males, the prevalence of obesity increased from 8% to 15% through the ages of 15–24 years. The prevalence of overweight and obesity were both 14% for females across all age groups. The prevalence of hypertension was low (4% males and 3% females) but the prevalence of high normal blood pressure was substantial (males 28% and females 14%).

In their summary, the authors noted that overweight, obesity and high normal blood pressure were highly prevalent among Australian young people. Low levels of physical activity were identified as a risk factor for obesity for both male and females.

Internal Medicine Journal 2017; 47:162–169

Summary

Abstract

Aim

Method

Results

Conclusion

Author Information

Acknowledgements

Correspondence

Correspondence Email

Competing Interests

For the PDF of this article,
contact nzmj@nzma.org.nz

View Article PDF

Treatment strategies for women with WHO group II anovulation

This report concerns a meta-analysis of trials on the topic of what is the most effective first line treatment for women with World Health Oganization group II anovulation wishing to conceive.

The data includes randomised controlled trials comparing eight ovulation induction treatments in these women. These treatments included clomiphene, letrozole, metformin, clomiphene and metformin combined, tamoxifen, gonadotrophins, laparoscopic ovarian drilling and placebo or no treatment. Pregnancy, defined preferably as clinical pregnancy, was chosen as the primary outcome.

Fifty-seven trials reporting on 8,082 women were included. All treatments were superior to placebo or no treatment in terms of pregnancy. The researchers concluded that letrozole and the combination of clomiphene and metformin are superior to clomiphene alone in terms of pregnancy.

BMJ 2017; 356:j138

Thromboprophylaxis after knee arthroscopy and lower-leg casting

The use of pharmacologic thromboprophylaxis after most orthopaedic interventions is well established, because it strongly reduces the risk of thrombosis while only slightly increasing the risk of bleeding. However, whether such treatment is beneficial after arthroscopy or lower-leg casting is disputed.

Two randomised trials conducted in the Netherlands examine this proposition. Patients were assigned to receive either low-molecular-weight heparin for eight days after arthroscopy or during the full period of casting or no anticoagulant therapy.

The incidence of venous thromboembolism was low in both trials and its incidence was uninfluenced by the use of anticoagulation.

N Engl J Med 2017; 376:515–25

Obesity and hypertension in Australian young people

This study aimed to characterise the prevalence of obesity and systolic hypertension in young people aged 15–24 years across Australia.

Data was obtained from the Australian Health Survey. Over 2,000 young people were involved. In males, the prevalence of obesity increased from 8% to 15% through the ages of 15–24 years. The prevalence of overweight and obesity were both 14% for females across all age groups. The prevalence of hypertension was low (4% males and 3% females) but the prevalence of high normal blood pressure was substantial (males 28% and females 14%).

In their summary, the authors noted that overweight, obesity and high normal blood pressure were highly prevalent among Australian young people. Low levels of physical activity were identified as a risk factor for obesity for both male and females.

Internal Medicine Journal 2017; 47:162–169

Summary

Abstract

Aim

Method

Results

Conclusion

Author Information

Acknowledgements

Correspondence

Correspondence Email

Competing Interests

Contact diana@nzma.org.nz
for the PDF of this article

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